5-HTP Griffonia Simplicifolia Seed Extract is a high-quality, natural, botanical raw material commonly used as a specialized ingredient in the nutraceutical, dietary supplement, and functional formulation industries around the world. A standardized natural extract from the seeds of the climbing shrub of West Africa, Griffonia simplicifolia, which is intrinsic to cellular biochemical pathways as a naturally occurring amino acid intermediate, is available in a high-purity format to bulk manufacturers and formulators. The raw ingredient is offered with standardized assays (typically up to 98% via HPLC) for precise dosage, batch-to-batch stability, and seamless incorporation into solid dosage formulations like capsules, tablets, and powders, for applications like industrial formulation, OEM/ODM production, and advanced finished product manufacturing. Physically, it has a wonderful solubility, flowability, chemical stability, according to strict international quality control standards, it is non-GMO, has a very tight heavy metal safety, solvent safety and microbiological safety. It provides a consistent and quality structural component for cognitive support, relaxation, and wellness formulations, helping industrial commercial partners to create product lines that fit the fast-changing wholesale market needs and comply with the clean label regulations.

Test Item | Specification | Result (Example Only) | Test Method |
PHYSICAL & ORGANOLEPTIC TESTS | |||
Appearance | White to off-white fine powder | Off-white fine powder | Visual examination |
Odor | Characteristic | Conforms | Organoleptic |
Identification | Positive for 5-HTP | Conforms | HPLC / IR |
ACTIVE INGREDIENT & PHYSICOCHEMICAL TESTS | |||
5-HTP Content (on dry basis) | ≥ 98.0% | 98.3% | HPLC |
Loss on Drying | ≤ 5.0% | 2.1% | USP <731> / validated method |
Water Content | Report/set limit as applicable | 1.8% | Karl Fischer |
Total Ash | ≤ 1.0% | 0.4% | Gravimetric / validated method |
pH (1% solution) | 4.0–7.0 | 5.6 | pH meter |
Particle Size | ≥ 95% passes 80 mesh | 98.0% passes | Sieve analysis |
Bulk Density | Report / set range as applicable | 0.48 g/mL | Validated physical method |
Residual Solvents / Process Residues | |||
Methanol | NMT 3,000 mg/kg | 120 mg/kg | GC |
Ethanol | NMT 5,000 mg/kg | 350 mg/kg | GC |
Other Residual Solvents | Conforms to solvents used and applicable limits | Not detected / N.A. | GC |
HEAVY METALS | |||
Lead (Pb) | ≤ 1.0 mg/kg | 0.12 mg/kg | ICP-MS |
Arsenic (As) | ≤ 1.0 mg/kg | 0.08 mg/kg | ICP-MS |
Cadmium (Cd) | ≤ 1.0 mg/kg | 0.05 mg/kg | ICP-MS |
Mercury (Hg) | ≤ 0.1 mg/kg | < 0.01 mg/kg | ICP-MS |
MICROBIOLOGICAL TESTS | |||
Total Plate Count | ≤ 1,000 CFU/g | 120 CFU/g | USP <61> / equivalent |
Yeast and Mold | ≤ 100 CFU/g | 20 CFU/g | USP <61> / equivalent |
Escherichia coli | Absent in 10 g | Absent | USP <62> / equivalent |
Salmonella | Absent in 25 g | Absent | USP <62> / equivalent |
Staphylococcus aureus | Absent in 10 g | Absent | Validated microbiological method |
Pesticide Residues | |||
Pesticide Multi-Residue Screen | Complies with applicable market limits | Conforms | LC-MS/MS and GC-MS/MS |
Mycotoxins | |||
Aflatoxin B1 | ≤ 5 µg/kg | < 1 µg/kg | HPLC-FLD / LC-MS/MS |
Total Aflatoxins (B1+B2+G1+G2) | ≤ 10 µg/kg | < 2 µg/kg | HPLC-FLD / LC-MS/MS |
The global market for Griffonia 5-HTP is growing steadily with strong macro-level industry growth in the manufacturing of functional food, nutraceuticals, and natural supplements. This is in part made possible by the global consumer trend towards purchasing products that contain plant-derived ingredients as active substances rather than synthetic ones that are standardized. Today's consumers are increasingly interested in a seamless integration of their lifestyle, traceability of ingredients/ingredient sources, and a commitment to non-GMO and sustainable sourcing, driving up pull-through demand for enterprise brand portfolios. This means commercial formulators, procurement, and OEM/ODM/ ODMs need to rely more on standardized, high-purity raw extracts that ensure chemical stability from batch to batch, analytical documentation (HPLC testing), and compatibility to be processed across a variety of delivery formats such as capsules, tablets, functional beverages, and wellness blends. But with quality assurance and full chain traceability becoming increasingly required in regional regulatory systems around the globe, enterprise market leaders are exploiting the versatility and premiumity as a valuable plant-based botanical anchor for genuine wellness for the long term.
Technically and physiochemically, 5-HTP is unique, with functional properties that can be very important to the industrial formulator and process engineer. The standardised extract is based on the polar hydroxyl and carboxyl functional groups, which enable it to be moderately to highly water-soluble, compared to non-hydroxylated aromatic compounds, chemically. The high-purity raw material is physically manifested as an off-white to fine crystalline powder with a controlled particle size distribution (typically 100% passing 80 mesh), which allows high dissolution rates, bulk density uniformity, and excellent flow properties, which are essential for high-speed automated lines and direct compression tableting lines. It is very thermally stable under normal dry processing temperatures and should be processed at neutral to slightly acidic (pH 4.5-6.5) conditions to avoid oxidative degradation in liquid or high moisture matrices. In addition, 5-HTP Griffonia Seed Extract has minimal hygroscopicity, low residual solvent content (in compliance with USP/EP requirements), and excellent compatibility with common excipients like microcrystalline cellulose, silica, and dicalcium phosphate, offering the formulation engineer a predictable and highly stable botanical building block for solid dosage forms and premix blends.

1. Multi-Nutrient Stacked Capsules & Tablets:
Griffonia Seed Extract Powder can be used as a key active ingredient and is also compatible with other classic hard-shell capsule and compressed tablet matrix formulations with synergistic botanical extracts, vitamins, and minerals.
2. Functional Micro-Pills & Time-Release Pellets:
Multiparticulate coating technology offers the opportunity for the formulation of sustained-release granules, dual-phase beadlet-in-capsule formulations, or combinations for controlled physical release profiles.
3. Liquid Wellness Drops & Oral Sprays:
Due to its good aqueous solubility, the process engineer can use it to add the extract to stable, non-settling liquid suspensions, sublingual sprays, and concentrated liquid tincture lines.
4. Solid Functional Confectioneries & Gummies:
The ingredient is developed for use in clean label confectionery production and is thermally processable, ideal for pectin combinations with pectin or gelatin at high heat and suitable for chewy bites.
5. Effervescent Powders & Drink Mix Sachets:
The extract is very well flowable in dry-mix sticks to be mixed with cold water, or in effervescent mixes for beverages, because of its good mesh uniformity.
Q1: What standard purity specifications are available for bulk orders?
A: We supply standardized Griffonia simplicifolia Seed Extract containing high purity levels of 5-HTP up to 98% (HPLC), and also provide custom specification options to suit the different regulatory requirements in each region.
Q2: What is the typical shelf life and recommended storage condition?
A: If the ingredient is stored in a cool and dry location, out of direct sunlight, high heat, and humidity, in sealed food-grade containers, it will have a 24-month shelf life.
Q3: How does this raw material perform in liquid and gummy formulations?
A: It has good aqueous solubility and good uniformity in the fine mesh, is dispersed evenly in liquid bases, and has excellent thermal stability for the high-temperature processing of gummy matrix.
Q4: What compliance documentation is provided with each shipment?
A: Each commercial batch contains a detailed Certificate of Analysis (COA), and each COA includes an assay purity report, heavy metals, residual solvents, moisture content, and a full microbiological testing report.
Q5: What are the standard packaging options and Minimum Order Quantity (MOQ)?
A: Standard commercial packaging is a 25 kg Fiber drum which has two inner PE bags inside. MOQs can be customized, such as trial samples of 1kg for R&D and formula testing.
To get a special quote, order laboratory tests, or consult our specialists about your particular formulation needs, please call us atinfo@scigroundbio.com or fill in the form, and our special export team will help you with a special solution to your buying needs.



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