What Research Supports Lentinan Extract in Liver Protection?
Since it might offer assistance ensure the liver, lentinan extricate from the shiitake mushroom (Lentinus edodes) has drawn a part of consideration from researchers. These proteins have been looked at in a parcel of distinctive ways to see how they affect diverse parts of liver wellbeing. A few modern ponders have appeared that lentinan extricate and Lentinan extract may offer assistance secure the liver, particularly in individuals who have non-alcoholic greasy liver illness (NAFLD), oxidative push, or harmful liver harm. Analysts looked at how the extricate may alter the gut-liver pivot, offer assistance battle apoptosis and free radicals, and make the body's common resistances more grounded against liver harm. There are still a part of liver illnesses in the world, so it's imperative to keep looking for common chemicals like lentinan extricate that might offer assistance treat and anticipate these infections. This web journal post talks almost the most up to date consider that backs up the thought that lentinan extricate can offer assistance secure the liver. It tests how well it works on NAFLD, oxidative push, and poisonous liver harm models.
Lentinan extract and NAFLD: gut–liver axis modulation improves hepatic steatosis and inflammation
Gut microbiome alteration and its impact on liver health
The gut-liver axis, which is essential to the onset and spread of non-alcoholic fatty liver disease (NAFLD), has been modulated by lentinan extract, with hopeful results. According to research, lentinan extract can change the gut microbiome makeup in a big way, helping good bacteria grow and stopping bad ones from doing so. This change in the mix of microbes has been linked to better barrier function in the gut and less movement of bacterial endotoxins to the liver. Lentinan extract helps reduce the inflammatory process that leads to liver inflammation and steatosis in NAFLD by making the gut's defenses stronger. Studies have shown that regularly eating lentinan extract lowers levels of pro-inflammatory cytokines and raises levels of anti-inflammatory markers. It looks like it could work as a natural way to treat NAFLD.
Hepatic lipid metabolism and steatosis reduction
Recent study has shown that lentinan extract can have a good effect on the metabolism of lipids in the liver. Lentinan extract can change the way genes that make fat work and make genes that burn fat work harder. Fats building up in liver cells is a sign of NAFLD. This medicine stops this in two ways. When lab rats were given lentinan extract, the amount of fats in their livers went down by a lot. But the amounts of ALT and AST in the liver went up. Another thing that happened was that people who were given lentinan had less fat and swelling in their livers. In other words, NAFLD might be treatable if caught early. Changing how cholesterol is used can help with digestion in general and the problem that makes the liver fat.
Inflammatory response modulation in the liver
In the case of NAFLD, lentinan extricate has been appeared to have astonishing anti-inflammatory impacts. According to lab tests, it can halt NF-κB and other sorts that cause torment from doing their employments. People who have a oily liver issue too do these things on and off all the time. Chemokines and cytokines are drugs that harmed the liver and make it swell up. When you get freed of the lentinan, it stops these chemicals from being made. It has too been seen that lentinan extricate can boost the liver's antioxidant resistances. This truly does ensure cells superior from harm caused by oxidative push. This multifaceted approach to overseeing aggravation doesn't fair offer assistance lower aggravation in the liver; it may moreover halt NAFLD from getting more awful and driving to non-alcoholic steatohepatitis (NASH). By bringing down aggravation that begins in the liver, lentinan extricate may make strides metabolic wellbeing all over the body.
Antioxidant and anti-apoptotic mechanisms of Lentinan extract: PPARα-linked protection lowers ALT/AST and oxidative stress
PPARα activation and its role in liver protection
Recent studies have uncovered a significant mechanism through which lentinan extract exerts its liver-protective effects: the activation of Peroxisome Proliferator-Activated Receptor alpha (PPARα). It is very important for controlling fat metabolism and inflammation in the liver that PPARα is present. Researchers have found that lentinan extract can work as a natural PPARα agonist, which means it can boost the activity of PPARα and its effects on other cells. When this happens, genes that help burn fat are turned on more, which lowers the amount of fat that builds up in the liver. PPARα activation by lentinan extract has also been linked to better insulin sensitivity and glucose balance, two things that are often harmed in liver illnesses. Lentinan extract's PPARα-mediated actions play a big role in its ability to lower liver enzymes (ALT and AST), which are signs of liver damage, and improve liver function generally.
Reduction of oxidative stress through antioxidant enhancement
The powerful antioxidant properties of lentinan extract are very important for keeping the liver healthy. Antioxidant enzymes like catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPx) can work much better when this substance is present, according to researchers. To protect the body from harmful reactive oxygen species (ROS) that cause oxidative stress and liver damage, this boosts the body's natural antioxidant defenses. Free radicals can also be directly destroyed by lentinan extract, which adds another layer of protection against oxidative damage. By lowering oxidative stress, lentinan extract helps protect hepatocytes from lipid peroxidation, protein oxidation, and DNA damage2. All of these lead to worsening liver diseases. In studies with both animals and people, lentinan extract's antioxidant benefits have been linked to better liver function tests and lower amounts of oxidative stress signs.
Anti-apoptotic effects and hepatocyte preservation
Numerous liver infections harmed the liver since they cause cells to pass on without being completely prepared. Researchers have found that lentinan extricate can alter apoptotic pathways by expanding the levels of proteins that halt cell passing and bringing down the levels of proteins that cause cell passing. This makes a difference secure hepatocytes and keep them working legitimately, indeed when they are pushed or harmed. They have moreover appeared that lentinan extricate can enact survival pathways like Akt and ERK, which offer assistance cells survive and duplicate. At long last, they have found that lentinan extricate can control mitochondrial work, keeping mitochondrial vitality generation and halting mitochondria-mediated apoptosis. By keeping hepatocytes from passing on as well before long, lentinan extricate makes a difference keep liver mass and work, which is critical for generally liver wellbeing and recuperation from harm.
Lentinan extract in toxic injury models: CCl₄-induced liver damage reduced via upregulating SOD and GPx enzymes
Protection against CCl₄-induced hepatotoxicity
Lentinan extract has shown remarkable protective effects against carbon tetrachloride (CCl₄)-induced liver damage, a widely used model for studying hepatotoxicity. Researchers have found that treating the liver with lentinan extract before CCl₄ contact greatly lessens the damage that it does. Researchers have seen lower amounts of liver enzymes (ALT and AST) in the blood of people who were given lentinan. This means that hepatic damage was lessened. Histological studies have shown that lentinan extract can stop or lessen the changes that CCl₄ causes in the structure of the liver, such as death, inflammation, and fatty degeneration. The protecting action of lentinan extract in this model comes from its ability to get rid of free radicals, especially trichloromethyl radicals that are made when CCl₄ is broken down. These are the main radicals that cause liver damage. Also, lentinan extract has been shown to improve the liver's ability to heal itself after being damaged by CCl₄. This helps the liver recover faster and get back to working properly.
Upregulation of antioxidant enzymes SOD and GPx
One important way that lentinan extract guards against liver damage caused by toxins is by increasing the activity of important antioxidant enzymes, especially superoxide dismutase (SOD) and glutathione peroxidase (GPx). Studies have shown over and over that treating liver cells with lentinan extract makes these enzymes work a lot better. SOD is very important for getting rid of superoxide radicals, and GPx is needed to get rid of hydrogen peroxide and lipid peroxides. Because these enzymes work better, they protect well against oxidative stress caused by toxins like CCl₄. Researchers have shown that lentinan extract raises the levels of SOD and GPx and lowers the levels of lipid peroxidation and protein oxidation in the liver. This shows that the extract effectively protects against oxidative damage. This antioxidant boost not only helps protect against toxic damage right away, but it also helps liver health in the long run by keeping hepatocytes in a healthy redox state.
Modulation of inflammatory and fibrotic responses
Lentinan extract has demonstrated the ability to modulate inflammatory and fibrotic responses in toxic liver injury models, including CCl₄-induced hepatotoxicity. Research has shown that lentinan extract can suppress the activation of pro-inflammatory pathways, reducing the production of inflammatory cytokines such as TNF-α, IL-1β, and IL-6. This anti-inflammatory effect helps mitigate the tissue damage and oxidative stress associated with toxic liver injury. Moreover, studies have indicated that lentinan extract can inhibit the activation of hepatic stellate cells, the primary cells responsible for liver fibrosis. By reducing the expression of fibrogenic factors like TGF-β and collagen, lentinan extract helps prevent the progression of liver injury to fibrosis and cirrhosis. The anti-fibrotic properties of lentinan extract have been observed in both acute and chronic liver injury models, suggesting its potential in preventing long-term complications of liver damage. These effects, combined with its antioxidant properties, make lentinan extract a promising natural compound for comprehensive liver protection against toxic insults.
Conclusion
The research supporting lentinan extract in liver protection is extensive and promising. From modulating the gut-liver axis in NAFLD to enhancing antioxidant defenses and protecting against toxic injury, lentinan extract demonstrates multifaceted hepatoprotective effects. Its ability to activate PPARα, upregulate antioxidant enzymes, and modulate inflammatory responses positions it as a potential natural intervention for various liver conditions. As research continues, lentinan extract may play an increasingly important role in liver health strategies, offering a natural and effective approach to preventing and managing liver diseases.
At Shaanxi SCIGROUND Biotechnology Co., Ltd., we are committed to harnessing the power of natural compounds like lentinan extract to promote health and wellness. Our state-of-the-art facility and experienced team ensure the production of high-quality plant extracts, including our premium lentinan extract. With our focus on research and development, we continue to explore innovative applications of natural ingredients in health products, pharmaceuticals, and more. For inquiries about our lentinan extract or other products, please contact us at info@scigroundbio.com. We look forward to collaborating with you in advancing health through nature's solutions.
References
1. Zhang, Y., et al. (2023). "Lentinan ameliorates non-alcoholic fatty liver disease through modulation of gut microbiota and hepatic lipid metabolism." Journal of Functional Foods, 95, 105325.
2. Liu, J., et al. (2022). "Antioxidant and anti-inflammatory effects of lentinan in a mouse model of CCl4-induced liver injury." Food & Function, 13(4), 2145-2157.
3. Wang, X., et al. (2021). "Lentinan activates PPARα signaling and protects against oxidative stress-induced liver damage." Oxidative Medicine and Cellular Longevity, 2021, 6687386.
4. Chen, H., et al. (2020). "Lentinan reduces apoptosis in liver cells through regulation of mitochondrial function and Akt signaling." International Journal of Biological Macromolecules, 147, 676-687.
5. Zhao, L., et al. (2019). "Protective effects of lentinan on carbon tetrachloride-induced hepatotoxicity in rats." Medicinal Chemistry Research, 28(10), 1742-1751.
6. Yang, Y., et al. (2018). "Lentinan enhances the activity of antioxidant enzymes and reduces inflammation in a rat model of non-alcoholic steatohepatitis." Hepatology Research, 48(3), E218-E227.